ABSTRACT
The effect of endurance training on lipid profile and cardiovascular endurance in normal rat after Bunium Persicum Extract [BPE] administration has been previously investigated. In the present study, the effect of co-administration of endurance training and persicum extract on plasma lipid and lipoproteins in hypercholesterolemic male mice was examined. In this experimental study, 60 male mice were, randomly, divided into 4 groups: Vehicle, Endurance Training [ET], Bunium Persicum Extract Administer [BPEA] and ET-BPEA group. The Exercise protocol was performed at a speed of 18 m/min, 40 min/day, 5 day/week for 6-weeks. The Bunium Persicum Extract was also administered in the same period and the desired dose [0.8 mg] was reconstituted in 0.4 ml of distilled water. The amount of Triglyceride [TG], Total Cholesterol [TC], HDL-c, LDL-c and Body Weight were registered at the beginning and also at the end of the 6 weeks. Data were analysed using one-way ANOVA method. The results indicated that the 6-week endurance training accompanied by Bunium Persicum aquous extract administration reduced TC [pretest; 297.7 +/- 37.08, post test; 146.1 +/- 30.8, p=0.019] and LDL-c concentrations [pretest; 151.8 +/- 14.4, post test; 0.12 +/- 8.7, p=0.00l]. On the other hand, Bunium Persicum aquous extract administration increased HDL-c concentration significantly [pretest; 75.9 +/- 12.1, post test; 119.9 +/- 17.9, p=0.003]. Furthermore, the results showed that body weight changes were not significant. These results suggest that co-administration of BPE and ET could significantly affect plasma lipid and lipoproteins. Therfore performing such program maybe useful for preventing cardiovascular diseases